General and Efficient Protocol for Formylation of Aromatic and Heterocyclic Phenols

Kamil Skonieczny; Georgios Charalambidis; Mariusz Tasior; Maciej Krzeszewski; Ayfer Kalkan-Burat; Athanassios G. Coutsolelos; Daniel T. Gryko

doi:10.1055/s-0032-1317500

Synthesis, Table of Contents

Synthesis 2012; 44(23): 3683-3687
DOI: 10.1055/s-0032-1317500

paper

General and Efficient Protocol for Formylation of Aromatic and Heterocyclic Phenols

Kamil Skonieczny

^aInstitute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland Fax: +48(22)6326681 Email: dtgryko@icho.edu.pl

,

Georgios Charalambidis

^bChemistry Department, University of Crete, Voutes Campus, P.O. Box 2208, 71003 Heraklion, Crete, Greece Email: coutsole@chemistry.uoc.gr

,

Mariusz Tasior

^aInstitute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland Fax: +48(22)6326681 Email: dtgryko@icho.edu.pl

,

Maciej Krzeszewski

^cWarsaw University of Technology, Faculty of Chemistry, Noakowskiego 3, 00-664 Warsaw, Poland

,

Ayfer Kalkan-Burat

^aInstitute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland Fax: +48(22)6326681 Email: dtgryko@icho.edu.pl

,

Athanassios G. Coutsolelos*

^bChemistry Department, University of Crete, Voutes Campus, P.O. Box 2208, 71003 Heraklion, Crete, Greece Email: coutsole@chemistry.uoc.gr

,

Daniel T. Gryko*

^aInstitute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland Fax: +48(22)6326681 Email: dtgryko@icho.edu.pl

^cWarsaw University of Technology, Faculty of Chemistry, Noakowskiego 3, 00-664 Warsaw, Poland

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Abstract

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Abstract

A convenient, general procedure for formylation of diverse range of phenols with the Duff protocol has been developed. The procedure gives dialdehydes when possible.

Key words

aldehydes - arenes - electrophilic aromatic substitution - heterocycles - phenols

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References

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